ETS transcription factors induce a unique UV damage signature that drives recurrent mutagenesis in melanoma

Many factors contribute to mutation hotspots in cancer cells. Here the authors map UV damage at single-nucleotide resolution across the human genome and find that binding sites of ETS transcription factors are especially prone to forming UV lesions, leading to mutation hotspots in melanoma.

Bibliographic Details
Main Authors:	Peng Mao, Alexander J. Brown, Shingo Esaki, Svetlana Lockwood, Gregory M. K. Poon, Michael J. Smerdon, Steven A. Roberts, John J. Wyrick
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018-07-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-018-05064-0

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spelling	doaj-1f4e7dc1330c42998833ca4f03cc3b392021-05-11T10:16:52ZengNature Publishing GroupNature Communications2041-17232018-07-019111310.1038/s41467-018-05064-0ETS transcription factors induce a unique UV damage signature that drives recurrent mutagenesis in melanomaPeng Mao0Alexander J. Brown1Shingo Esaki2Svetlana Lockwood3Gregory M. K. Poon4Michael J. Smerdon5Steven A. Roberts6John J. Wyrick7School of Molecular Biosciences, Washington State UniversitySchool of Molecular Biosciences, Washington State UniversityDepartment of Chemistry, Georgia State UniversityPaul G. Allen School for Global Animal Health, Washington State UniversityDepartment of Chemistry, Georgia State UniversitySchool of Molecular Biosciences, Washington State UniversitySchool of Molecular Biosciences, Washington State UniversitySchool of Molecular Biosciences, Washington State UniversityMany factors contribute to mutation hotspots in cancer cells. Here the authors map UV damage at single-nucleotide resolution across the human genome and find that binding sites of ETS transcription factors are especially prone to forming UV lesions, leading to mutation hotspots in melanoma.https://doi.org/10.1038/s41467-018-05064-0
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Peng Mao Alexander J. Brown Shingo Esaki Svetlana Lockwood Gregory M. K. Poon Michael J. Smerdon Steven A. Roberts John J. Wyrick
spellingShingle	Peng Mao Alexander J. Brown Shingo Esaki Svetlana Lockwood Gregory M. K. Poon Michael J. Smerdon Steven A. Roberts John J. Wyrick ETS transcription factors induce a unique UV damage signature that drives recurrent mutagenesis in melanoma Nature Communications
author_facet	Peng Mao Alexander J. Brown Shingo Esaki Svetlana Lockwood Gregory M. K. Poon Michael J. Smerdon Steven A. Roberts John J. Wyrick
author_sort	Peng Mao
title	ETS transcription factors induce a unique UV damage signature that drives recurrent mutagenesis in melanoma
title_short	ETS transcription factors induce a unique UV damage signature that drives recurrent mutagenesis in melanoma
title_full	ETS transcription factors induce a unique UV damage signature that drives recurrent mutagenesis in melanoma
title_fullStr	ETS transcription factors induce a unique UV damage signature that drives recurrent mutagenesis in melanoma
title_full_unstemmed	ETS transcription factors induce a unique UV damage signature that drives recurrent mutagenesis in melanoma
title_sort	ets transcription factors induce a unique uv damage signature that drives recurrent mutagenesis in melanoma
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2018-07-01
description	Many factors contribute to mutation hotspots in cancer cells. Here the authors map UV damage at single-nucleotide resolution across the human genome and find that binding sites of ETS transcription factors are especially prone to forming UV lesions, leading to mutation hotspots in melanoma.
url	https://doi.org/10.1038/s41467-018-05064-0
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ETS transcription factors induce a unique UV damage signature that drives recurrent mutagenesis in melanoma

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