ETS transcription factors induce a unique UV damage signature that drives recurrent mutagenesis in melanoma
Many factors contribute to mutation hotspots in cancer cells. Here the authors map UV damage at single-nucleotide resolution across the human genome and find that binding sites of ETS transcription factors are especially prone to forming UV lesions, leading to mutation hotspots in melanoma.
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2018-07-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-05064-0 |