Arsenic trioxide induces regulatory functions of plasmacytoid dendritic cells through interferon-α inhibition

Arsenic trioxide induces regulatory functions of plasmacytoid dendritic cells through interferon-α inhibition

Arsenic trioxide (As2O3) is recently found to have therapeutic potential in systemic sclerosis (SSc), a life-threatening multi-system fibrosing autoimmune disease with type I interferon (IFN-I) signature. Chronically activated plasmacytoid dendritic cells (pDCs) are responsible for IFN-I secretion a...

Full description

Bibliographic Details
Main Authors: Yishan Ye, Laure Ricard, Lama Siblany, Nicolas Stocker, Frédéric De Vassoigne, Eolia Brissot, Baptiste Lamarthée, Arsène Mekinian, Mohamad Mohty, Béatrice Gaugler, Florent Malard
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Arsenic trioxide
Plasmacytoid dendritic cell
Immunotherapy
Systemic sclerosis
IFN-I
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383519309542

Internet

http://www.sciencedirect.com/science/article/pii/S2211383519309542

Similar Items