Transcriptomic Profiling of In Vitro Tumor-Stromal Cell Paracrine Crosstalk Identifies Involvement of the Integrin Signaling Pathway in the Pathogenesis of Mesenteric Fibrosis in Human Small Intestinal Neuroendocrine Neoplasms

Transcriptomic Profiling of In Vitro Tumor-Stromal Cell Paracrine Crosstalk Identifies Involvement of the Integrin Signaling Pathway in the Pathogenesis of Mesenteric Fibrosis in Human Small Intestinal Neuroendocrine Neoplasms

AimAnalysis of the pathophysiology of mesenteric fibrosis (MF) in small intestinal neuroendocrine tumors (SI-NETs) in an in vitro paracrine model and in human SI-NET tissue samples.MethodsAn indirect co-culture model of SI-NET cells KRJ-I and P-STS with stromal cells HEK293 was designed to evaluate...

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Bibliographic Details
Main Authors: Faidon-Marios Laskaratos, Ana Levi, Gert Schwach, Roswitha Pfragner, Andrew Hall, Dong Xia, Conrad von Stempel, Josephine Bretherton, Kessarin Thanapirom, Sarah Alexander, Olagunju Ogunbiyi, Jennifer Watkins, Tu Vinh Luong, Christos Toumpanakis, Dalvinder Mandair, Martyn Caplin, Krista Rombouts
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Oncology
Subjects:
neuroendocrine neoplasia
fibrosis
integrin
mesenteric desmoplasia
carcinoid
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.629665/full

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https://www.frontiersin.org/articles/10.3389/fonc.2021.629665/full

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