A unique intracellular tyrosine in neuroligin-1 regulates AMPA receptor recruitment during synapse differentiation and potentiation

Neuroligins are postsynaptic cell adhesion molecules thought to play roles in synaptic development and function. Here, authors show that phosphorylation of Y782 in neuroligin-1 modulates its role in differentiation and ability to recruit AMPARs including during long-term potentiation.

Bibliographic Details
Main Authors: Mathieu Letellier, Zsófia Szíber, Ingrid Chamma, Camille Saphy, Ioanna Papasideri, Béatrice Tessier, Matthieu Sainlos, Katalin Czöndör, Olivier Thoumine
Format: Article
Language:English
Published: Nature Publishing Group 2018-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-06220-2