A Developed NK-92MI Cell Line with Siglec-7neg Phenotype Exhibits High and Sustainable Cytotoxicity against Leukemia Cells

A Developed NK-92MI Cell Line with Siglec-7neg Phenotype Exhibits High and Sustainable Cytotoxicity against Leukemia Cells

Altered sialic acid processing that leads to upregulation of cell surface sialylation is recognized as a key change in malignant tissue glycosylation. This cancer-associated hypersialylation directly impacts the signaling interactions between tumor cells and their surrounding microenvironment, espec...

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Bibliographic Details
Main Authors: Chin-Han Huang, Yi-Jen Liao, Ting-Hsi Fan, Tzeon-Jye Chiou, Yen-Hsi Lin, Yuh-Ching Twu
Format: Article
Language:English
Published: MDPI AG 2018-04-01
Series:International Journal of Molecular Sciences
Subjects:
glycosylation
hypersialylation
immuno-surveillance
natural killer cell
Siglec-7
Online Access:http://www.mdpi.com/1422-0067/19/4/1073

Internet

http://www.mdpi.com/1422-0067/19/4/1073

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