Transcriptional signatures of unfolded protein response implicate the limitation of animal models in pathophysiological studies

Transcriptional signatures of unfolded protein response implicate the limitation of animal models in pathophysiological studies

Background: The unfolded protein response (UPR) refers to intracellular stress signaling pathways that protect cells from the stress caused by accumulation of unfolded or misfolded proteins in the endoplasmic reticulum (ER). The UPR signaling is crucially involved in the initiation and progression o...

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Bibliographic Details
Main Authors: Ze Zheng, Guohui Wang, Li Li, Jeffery Tseng, Fei Sun, Xuequn Chen, Lin Chang, Henry Heng, Kezhong Zhang
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2016-01-01
Series:Environmental Disease
Subjects:
Animal models
endoplasmic reticulum stress
environmental stress
transcriptional signature
unfolded protein response
Online Access:http://www.environmentmed.org/article.asp?issn=2468-5690;year=2016;volume=1;issue=1;spage=24;epage=30;aulast=Zheng

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http://www.environmentmed.org/article.asp?issn=2468-5690;year=2016;volume=1;issue=1;spage=24;epage=30;aulast=Zheng

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