The Putative Role of the Non-Gastric H+/K+-ATPase ATP12A (ATP1AL1) as Anti-Apoptotic Ion Transporter: Effect of the H+/K+ ATPase Inhibitor SCH28080 on Butyrate-Stimulated Myelomonocytic HL-60 Cells

The Putative Role of the Non-Gastric H+/K+-ATPase ATP12A (ATP1AL1) as Anti-Apoptotic Ion Transporter: Effect of the H+/K+ ATPase Inhibitor SCH28080 on Butyrate-Stimulated Myelomonocytic HL-60 Cells

Background/Aims: The ATP12A gene codes for a non-gastric H+/K+ ATPase, which is expressed in a wide variety of tissues. The aim of this study was to test for the molecular and functional expression of the non-gastric H+/K+ ATPase ATP12A/ATP1AL1 in unstimulated and butyrate-stimulated (1 and 10 mM) h...

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Bibliographic Details
Main Authors: Martin Jakab, Sabine Hofer, Andrea Ravasio, Felix Huber, Sabine Schmidt, Wolfgang Hitzl, John P. Geibel, Johannes Fürst, Markus Ritter
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2014-10-01
Series:Cellular Physiology and Biochemistry
Subjects:
H+/K+-ATPase
ATP12A
ATP1AL1
HL-60 cells
Butyrate
Apoptosis
Cell volume
Online Access:http://www.karger.com/Article/FullText/366355

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http://www.karger.com/Article/FullText/366355

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