Microbiota-derived butyrate limits the autoimmune response by promoting the differentiation of follicular regulatory T cells

Microbiota-derived butyrate limits the autoimmune response by promoting the differentiation of follicular regulatory T cells

Background: Rheumatoid arthritis (RA) is a chronic debilitating autoimmune disorder with a high prevalence, especially in industrialized countries. Dysbiosis of the intestinal microbiota has been observed in RA patients. For instance, new-onset untreated RA (NORA) is associated with the underreprese...

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Bibliographic Details
Main Authors: Daisuke Takahashi, Naomi Hoshina, Yuma Kabumoto, Yuichi Maeda, Akari Suzuki, Hiyori Tanabe, Junya Isobe, Takahiro Yamada, Kisara Muroi, Yuto Yanagisawa, Atsuo Nakamura, Yumiko Fujimura, Aiko Saeki, Mizuki Ueda, Ryohtaroh Matsumoto, Hanako Asaoka, Julie M. Clarke, Yohsuke Harada, Eiji Umemoto, Noriko Komatsu, Takaharu Okada, Hiroshi Takayanagi, Kiyoshi Takeda, Michio Tomura, Koji Hase
Format: Article
Language:English
Published: Elsevier 2020-08-01
Series:EBioMedicine
Subjects:
Rheumatoid arthritis
Intestinal microbiota
Butyrate
Follicular regulatory T cells
Autoimmunity
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396420302887

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http://www.sciencedirect.com/science/article/pii/S2352396420302887

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