DYRK1A-mediated phosphorylation of GluN2A at Ser1048 regulates the surface expression and channel activity of GluN1/GluN2A receptors

DYRK1A-mediated phosphorylation of GluN2A at Ser1048 regulates the surface expression and channel activity of GluN1/GluN2A receptors

N-methyl-D-aspartate glutamate receptors (NMDARs) play a pivotal role in neural development and synaptic plasticity, as well as in neurological disease. Since NMDARs exert their function at the cell surface, their density in the plasma membrane is finely tuned by a plethora of molecules that regulat...

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Bibliographic Details
Main Authors: Cristina eGrau, Krisztina eArató, José M. Fernández-Fernández, Aitana eValderrama, Carlos eSindreu, Cristina eFillat, Isidro eFerrer, Susana ede la Luna, Xavier eAltafaj
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-10-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Down Syndrome
Endocytosis
Phosphorylation
NMDA receptors
receptors trafficking
DYRK1A
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00331/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00331/full

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