Specific ion channels contribute to key elements of pathology during secondary degeneration following neurotrauma

Specific ion channels contribute to key elements of pathology during secondary degeneration following neurotrauma

Abstract Background Following partial injury to the central nervous system, cells beyond the initial injury site undergo secondary degeneration, exacerbating loss of neurons, compact myelin and function. Changes in Ca2+ flux are associated with metabolic and structural changes, but it is not yet cle...

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Bibliographic Details
Main Authors: Ryan L. O’Hare Doig, Wissam Chiha, Marcus K. Giacci, Nathanael J. Yates, Carole A. Bartlett, Nicole M. Smith, Stuart I. Hodgetts, Alan R. Harvey, Melinda Fitzgerald
Format: Article
Language:English
Published: BMC 2017-08-01
Series:BMC Neuroscience
Subjects:
Secondary degeneration
Neurotrauma
Traumatic injury
Ion channel inhibitor
Axonal degeneration
Node of Ranvier
Online Access:http://link.springer.com/article/10.1186/s12868-017-0380-1

Internet

http://link.springer.com/article/10.1186/s12868-017-0380-1

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