Low dose endotoxin priming is accountable for coagulation abnormalities and organ damage observed in the Shwartzman reaction. A comparison between a single-dose endotoxemia model and a double-hit endotoxin-induced Shwartzman reaction

<p>Abstract</p> <p>The clinical response of sepsis to a systemic inflammatory infection may be complicated by disseminated intravascular coagulation or DIC. In order to experimentally study the syndrome of DIC, we aimed for a severe sepsis model complicated by disseminated coagulat...

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Bibliographic Details
Main Authors: Cate Hugo, Slofstra Sjoukje H, Spek C Arnold
Format: Article
Language:English
Published: BMC 2006-08-01
Series:Thrombosis Journal
Online Access:http://www.thrombosisjournal.com/content/4/1/13