Early prepubertal cyclophosphamide exposure in mice results in long-term loss of ovarian reserve, and impaired embryonic development and blastocyst quality.

Early prepubertal cyclophosphamide exposure in mice results in long-term loss of ovarian reserve, and impaired embryonic development and blastocyst quality.

<h4>Background</h4>Due to improved treatment, there is an increasing focus on the reproductive potential of survivors of childhood cancer. Cytotoxic chemotherapy accelerates the decline in the number of primordial follicles within the mammalian ovary at all ages, but effects on the devel...

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Bibliographic Details
Main Authors: Sujith Raj Salian, Shubhashree Uppangala, Aswathi Cheredath, Fiona D'Souza, Guruprasad Kalthur, Vinod C Nayak, Richard A Anderson, Satish Kumar Adiga
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0235140

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https://doi.org/10.1371/journal.pone.0235140

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