Hepcidin Increases Cytokines in Alzheimer’s Disease and Down’s Syndrome Dementia: Implication of Impaired Iron Homeostasis in Neuroinflammation

Hepcidin Increases Cytokines in Alzheimer’s Disease and Down’s Syndrome Dementia: Implication of Impaired Iron Homeostasis in Neuroinflammation

The liver-derived hormone hepcidin, a member of the defensin family of antimicrobial peptides, plays an important role in host defense and innate immunity due to its broad antibacterial and antiviral properties. Ferritin, an iron storage protein is often associated with iron deficiency, hypoferritin...

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Bibliographic Details
Main Authors: Animesh Alexander Raha, Seyedeh Deniz Ghaffari, James Henderson, Subhojit Chakraborty, Kieren Allinson, Robert P. Friedland, Anthony Holland, Shahid H. Zaman, Elizabeta B. Mukaetova-Ladinska, Ruma Raha-Chowdhury
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Aging Neuroscience
Subjects:
Alzheimer’s disease
Down’s syndrome dementia
ferritin
hepcidin
choroid plexus
macrophage activation syndrome
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2021.653591/full

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https://www.frontiersin.org/articles/10.3389/fnagi.2021.653591/full

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