Nbn and atm cooperate in a tissue and developmental stage-specific manner to prevent double strand breaks and apoptosis in developing brain and eye.

Nbn and atm cooperate in a tissue and developmental stage-specific manner to prevent double strand breaks and apoptosis in developing brain and eye.

Nibrin (NBN or NBS1) and ATM are key factors for DNA Double Strand Break (DSB) signaling and repair. Mutations in NBN or ATM result in Nijmegen Breakage Syndrome and Ataxia telangiectasia. These syndromes share common features such as radiosensitivity, neurological developmental defects and cancer p...

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Bibliographic Details
Main Authors: Paulo M G Rodrigues, Paulius Grigaravicius, Martina Remus, Gabriel R Cavalheiro, Anielle L Gomes, Maurício Rocha-Martins, Lucien Frappart, David Reuss, Peter J McKinnon, Andreas von Deimling, Rodrigo A P Martins, Pierre-Olivier Frappart
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3728324?pdf=render

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http://europepmc.org/articles/PMC3728324?pdf=render

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