Nuclear Egress Complexes of HCMV and Other Herpesviruses: Solving the Puzzle of Sequence Coevolution, Conserved Structures and Subfamily-Spanning Binding Properties

Nuclear Egress Complexes of HCMV and Other Herpesviruses: Solving the Puzzle of Sequence Coevolution, Conserved Structures and Subfamily-Spanning Binding Properties

Herpesviruses uniquely express two essential nuclear egress-regulating proteins forming a heterodimeric nuclear egress complex (core NEC). These core NECs serve as hexameric lattice-structured platforms for capsid docking and recruit viral and cellular NEC-associated factors that jointly exert nucle...

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Bibliographic Details
Main Authors: Manfred Marschall, Sigrun Häge, Marcus Conrad, Sewar Alkhashrom, Jintawee Kicuntod, Johannes Schweininger, Mark Kriegel, Josephine Lösing, Julia Tillmanns, Frank Neipel, Jutta Eichler, Yves A. Muller, Heinrich Sticht
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Viruses
Subjects:
human cytomegalovirus (HCMV)
nuclear egress complex (NEC)
core NEC crystal structures
α-, β-, γ-herpesviral NECs
sequence coevolution
highly conserved structures
Online Access:https://www.mdpi.com/1999-4915/12/6/683

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https://www.mdpi.com/1999-4915/12/6/683

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