Parameter sensitivity analysis for a stochastic model of mitochondrial apoptosis pathway.

Understanding how gene alterations induce oncogenesis plays an important role in cancer research and may be instructive for cancer prevention and treatment. We conducted a parameter sensitivity analysis to the mitochondrial apoptosis model. Both a nonlinear bifurcation analysis of the deterministic...

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Bibliographic Details
Main Authors: Xianli Chen, Xiaoguang Li, Wei Zhao, Tiejun Li, Qi Ouyang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC6005494?pdf=render