Identification of a novel sulfonated oxysterol, 5-cholesten-3β,25-diol 3-sulfonate, in hepatocyte nuclei and mitochondria

Identification of a novel sulfonated oxysterol, 5-cholesten-3β,25-diol 3-sulfonate, in hepatocyte nuclei and mitochondria

This study reports the discovery of a novel sulfonated oxysterol found at high levels in the mitochondria and nuclei of primary rat hepatocytes after overexpression of the gene encoding steroidogenic acute regulatory protein (StarD1). Forty-eight hours after infection of primary rat hepatocytes with...

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Bibliographic Details
Main Authors: Shunlin Ren, Phillip Hylemon, Zong-Ping Zhang, Daniel Rodriguez-Agudo, Dalila Marques, Xiaobo Li, Huiping Zhou, Gregorio Gil, William M. Pandak
Format: Article
Language:English
Published: Elsevier 2006-05-01
Series:Journal of Lipid Research
Subjects:
nucleus
steroidogenic acute regulatory protein
cholesterol transporter
bile acids
cholesterol metabolism
nuclear oxysterol ligands
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520332570

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http://www.sciencedirect.com/science/article/pii/S0022227520332570

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