Chlorine inhalation induces acute chest syndrome in humanized sickle cell mouse model and ameliorated by postexposure hemopexin

Chlorine inhalation induces acute chest syndrome in humanized sickle cell mouse model and ameliorated by postexposure hemopexin

Triggering factors of Acute Chest Syndrome (ACS) is a leading cause of death in patients with Sickle Cell Disease (SCD) and targeted therapies are limited. Chlorine (Cl2) inhalation happens frequently, but its role as a potential trigger of ACS has not been determined. In this study, we hypothesized...

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Bibliographic Details
Main Authors: Ammar Saadoon Alishlash, Muna Sapkota, Israr Ahmad, Kelsey Maclin, Noor A. Ahmed, Adam Molyvdas, Stephen Doran, Carolyn J. Albert, Saurabh Aggarwal, David A. Ford, Namasivayam Ambalavanan, Tamas Jilling, Sadis Matalon
Format: Article
Language:English
Published: Elsevier 2021-08-01
Series:Redox Biology
Subjects:
Chlorinated lipids
Sickling
Red blood cells
Lung injury
Hypoxia
Hemolysis
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231721001671

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http://www.sciencedirect.com/science/article/pii/S2213231721001671

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