Measuring DNA hybridization using fluorescent DNA-stabilized silver clusters to investigate mismatch effects on therapeutic oligonucleotides

Measuring DNA hybridization using fluorescent DNA-stabilized silver clusters to investigate mismatch effects on therapeutic oligonucleotides

Abstract Background Short nucleic acid oligomers have found a wide range of applications in experimental physics, biology and medicine, and show potential for the treatment of acquired and genetic diseases. These applications rely heavily on the predictability of hybridization through Watson–Crick b...

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Bibliographic Details
Main Authors: Donny de Bruin, Nelli Bossert, Annemieke Aartsma-Rus, Dirk Bouwmeester
Format: Article
Language:English
Published: BMC 2018-04-01
Series:Journal of Nanobiotechnology
Subjects:
DNA hybridization
Mismatch dependencies
Therapeutic oligonucleotides
Silver nanoparticles
Online Access:http://link.springer.com/article/10.1186/s12951-018-0361-2

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http://link.springer.com/article/10.1186/s12951-018-0361-2

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