RRE-deleting self-inactivating and self-activating HIV-1 vectors for improved safety
Retroviruses have been shown to efficiently delete sequences between repeats as a consequence of the template switching ability of the viral reverse transcriptase. To evaluate this approach for deriving safety-modified lentiviral vectors, we created HIV-1 vectors engineered to delete the Rev-respons...
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| Format: | Article |
| Language: | English |
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PeerJ Inc.
2013-06-01
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| Series: | PeerJ |
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| Online Access: | https://peerj.com/articles/84.pdf |