Fe65-PTB2 Dimerization Mimics Fe65-APP Interaction

Fe65-PTB2 Dimerization Mimics Fe65-APP Interaction

Physiological function and pathology of the Alzheimer’s disease causing amyloid precursor protein (APP) are correlated with its cytosolic adaptor Fe65 encompassing a WW and two phosphotyrosine-binding domains (PTBs). The C-terminal Fe65-PTB2 binds a large portion of the APP intracellular domain (AIC...

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Bibliographic Details
Main Authors: Lukas P. Feilen, Kevin Haubrich, Paul Strecker, Sabine Probst, Simone Eggert, Gunter Stier, Irmgard Sinning, Uwe Konietzko, Stefan Kins, Bernd Simon, Klemens Wild
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-05-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Fe65
phosphotyrosine-binding domain (PTB)
homodimerization
amyloid precursor protein (APP)
AICD
Alzheimer’s disease
Online Access:http://journal.frontiersin.org/article/10.3389/fnmol.2017.00140/full

Internet

http://journal.frontiersin.org/article/10.3389/fnmol.2017.00140/full

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