IgG4 Autoantibodies Attenuate Systemic Lupus Erythematosus Progression by Suppressing Complement Consumption and Inflammatory Cytokine Production

IgG4 Autoantibodies Attenuate Systemic Lupus Erythematosus Progression by Suppressing Complement Consumption and Inflammatory Cytokine Production

Pathogenic autoantibodies can cause inflammation and tissue injury in systemic lupus erythematosus (SLE). Although IgG4 is considered non-inflammatory owing to the unique structure of its hinge region, the role of IgG4 autoantibodies in SLE remains largely unknown. The titers of serum anti-nuclear-I...

Full description

Bibliographic Details
Main Authors: Qingjun Pan, Haiyan Xiao, Lei Shi, Yiming He, Jun Cai, Jing Wu, Aifen Li, Lin Ye, Chen Yang, Hua-feng Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Immunology
Subjects:
systemic lupus erythematosus
autoantibody
IgG4
complement consumption
inflammatory cytokine
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01047/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.01047/full

Similar Items