Long-Term Stress Disrupts the Structural and Functional Integrity of GABAergic Neuronal Networks in the Medial Prefrontal Cortex of Rats

Long-Term Stress Disrupts the Structural and Functional Integrity of GABAergic Neuronal Networks in the Medial Prefrontal Cortex of Rats

Clinical and experimental data suggest that fronto-cortical GABAergic deficits contribute to the pathophysiology of major depressive disorder (MDD). To further test this hypothesis, we used a well characterized rat model for depression and examined the effect of stress on GABAergic neuron numbers an...

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Bibliographic Details
Main Authors: Boldizsár Czéh, Irina Vardya, Zsófia Varga, Fabia Febbraro, Dávid Csabai, Lena-Sophie Martis, Kristoffer Højgaard, Kim Henningsen, Elena V. Bouzinova, Attila Miseta, Kimmo Jensen, Ove Wiborg
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Cellular Neuroscience
Subjects:
depressive disorder
infralimbic cortex
interneuron
learning
NPY
patch-clamp
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2018.00148/full

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https://www.frontiersin.org/article/10.3389/fncel.2018.00148/full

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