Genetic Defects in Mitochondrial Dynamics in <i>Caenorhabditis elegans</i> Impact Ultraviolet C Radiation- and 6-hydroxydopamine-Induced Neurodegeneration

Genetic Defects in Mitochondrial Dynamics in <i>Caenorhabditis elegans</i> Impact Ultraviolet C Radiation- and 6-hydroxydopamine-Induced Neurodegeneration

Background: Parkinson&#8217;s disease (PD) is one of the most common neurodegenerative disorders involving devastating loss of dopaminergic neurons in the substantia nigra. Early steps in PD pathogenesis include mitochondrial dysfunction, and mutations in mitochondrial genes have been linked to...

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Bibliographic Details
Main Authors: Jessica H. Hartman, Claudia Gonzalez-Hunt, Samantha M. Hall, Ian T. Ryde, Kim A. Caldwell, Guy A. Caldwell, Joel N. Meyer
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:International Journal of Molecular Sciences
Subjects:
mitochondrial fusion
mitochondrial fission
mitophagy
dopaminergic neurodegeneration
6-hydroxydopamine
mitochondrial DNA damage
Online Access:https://www.mdpi.com/1422-0067/20/13/3202

Internet

https://www.mdpi.com/1422-0067/20/13/3202

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