P16INK4a Deletion Ameliorates Damage of Intestinal Epithelial Barrier and Microbial Dysbiosis in a Stress-Induced Premature Senescence Model of Bmi-1 Deficiency

P16INK4a Deletion Ameliorates Damage of Intestinal Epithelial Barrier and Microbial Dysbiosis in a Stress-Induced Premature Senescence Model of Bmi-1 Deficiency

This study aimed to determine whether Bmi-1 deficiency leads to intestinal epithelial barrier destruction and microbiota dysfunction, which members of the microbial community alter barrier function with age, and whether p16INK4a deletion could reverse the damage of intestinal epithelial barrier and...

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Bibliographic Details
Main Authors: Jiawen Zhou, Chenxing Hou, Haiyun Chen, Ziyue Qin, Zi’an Miao, Jingyu Zhao, Qiuyi Wang, Min Cui, Chunfeng Xie, Rong Wang, Qing Li, Guoping Zuo, Dengshun Miao, Jianliang Jin
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
inflammaging
TNF-α
Desulfovibrio
occludin
p16INK4a
Bmi-1
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.671564/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.671564/full

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