Extremely high concentration of mexotrexate in blood serum leading to development of acute renal failure in a patient with acute lymphoblastic leukemia after high-dose consolidation

Extremely high concentration of mexotrexate in blood serum leading to development of acute renal failure in a patient with acute lymphoblastic leukemia after high-dose consolidation

Acute renal failure (ARF) is one of rare and severe methotrexate(MT)-induced complications in patients with acute lymphoblastic leukemia. A case of MT-induced renal dysfunction with an extremely high serum MT concentration is reported. This toxicity required conduction of hemodiafiltration for extra...

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Bibliographic Details
Main Authors: Mariya Anatol'evna Pimenova, Andrey Nikolaevich Sokolov, Lyudmila Semenovna Biryukova, Elena Nikolaevna Ustinova, Inna Ivanovna Shaforostova, Irina Anatol'evna Donskova, Rashit Fargatovich Bogdanov, Elena Nikolaevna Parovichnikova, Valeriy Grigor'evich Savchenko, M A Pimenova, A N Sokolov, L S Biryukova, E N Ustinova, I I Shaforostova, I A Donskova, R F Bogdanov, E N Parovichnikova, V G Savchenko
Format: Article
Language:Russian
Published: "Consilium Medicum" Publishing house 2011-07-01
Series:Терапевтический архив
Subjects:
acute lymphoblastic leukemia
high dose methotrexate
acute renal failure
hemodiafiltration
homozygous mutation of methylene-tetrahydrofolate reductase gene
Online Access:https://ter-arkhiv.ru/0040-3660/article/view/30890

Internet

https://ter-arkhiv.ru/0040-3660/article/view/30890

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