Inadequate BiP availability defines endoplasmic reticulum stress

Inadequate BiP availability defines endoplasmic reticulum stress

How endoplasmic reticulum (ER) stress leads to cytotoxicity is ill-defined. Previously we showed that HeLa cells readjust homeostasis upon proteostatically driven ER stress, triggered by inducible bulk expression of secretory immunoglobulin M heavy chain (μs) thanks to the unfolded protein response...

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Bibliographic Details
Main Authors: Milena Vitale, Anush Bakunts, Andrea Orsi, Federica Lari, Laura Tadè, Alberto Danieli, Claudia Rato, Caterina Valetti, Roberto Sitia, Andrea Raimondi, John C Christianson, Eelco van Anken
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-03-01
Series:eLife
Subjects:
unfolded protein response
endoplasmic reticulum
proteotoxicity
ER stress
chaperones
BiP/GRP78
Online Access:https://elifesciences.org/articles/41168

Internet

https://elifesciences.org/articles/41168

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