Human valacyclovir hydrolase/biphenyl hydrolase-like protein is a highly efficient homocysteine thiolactonase.

Human valacyclovir hydrolase/biphenyl hydrolase-like protein is a highly efficient homocysteine thiolactonase.

Homocysteinylation of lysine residues by homocysteine thiolactone (HCTL), a reactive homocysteine metabolite, results in protein aggregation and malfunction, and is a well-known risk factor for cardiovascular, autoimmune and neurological diseases. Human plasma paraoxonase-1 (PON1) and bleomycin hydr...

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Bibliographic Details
Main Authors: Judit Marsillach, Stephanie M Suzuki, Rebecca J Richter, Matthew G McDonald, Peter M Rademacher, Michael J MacCoss, Edward J Hsieh, Allan E Rettie, Clement E Furlong
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4198189?pdf=render

Internet

http://europepmc.org/articles/PMC4198189?pdf=render

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