A murine model of falciparum-malaria by in vivo selection of competent strains in non-myelodepleted mice engrafted with human erythrocytes.

A murine model of falciparum-malaria by in vivo selection of competent strains in non-myelodepleted mice engrafted with human erythrocytes.

To counter the global threat caused by Plasmodium falciparum malaria, new drugs and vaccines are urgently needed. However, there are no practical animal models because P. falciparum infects human erythrocytes almost exclusively. Here we describe a reliable falciparum murine model of malaria by gener...

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Bibliographic Details
Main Authors: Iñigo Angulo-Barturen, María Belén Jiménez-Díaz, Teresa Mulet, Joaquín Rullas, Esperanza Herreros, Santiago Ferrer, Elena Jiménez, Alfonso Mendoza, Javier Regadera, Philip J Rosenthal, Ian Bathurst, David L Pompliano, Federico Gómez de las Heras, Domingo Gargallo-Viola
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2375113?pdf=render

Internet

http://europepmc.org/articles/PMC2375113?pdf=render

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