Inclusion complexation of the anticancer drug pomalidomide with cyclodextrins: fast dissolution and improved solubility

Inclusion complexation of the anticancer drug pomalidomide with cyclodextrins: fast dissolution and improved solubility

Pomalidomide (POM), a potent anticancer thalidomide analogue was characterized in terms of cyclodextrin complexation to improve its aqueous solubility and maintain its anti-angiogenic activity. The most promising cyclodextrin derivatives were selected by phase-solubility studies. From the investigat...

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Bibliographic Details
Main Authors: Zoltán-István Szabó, György Orbán, Enikő Borbás, Dóra Csicsák, Szabina Kádár, Béla Fiser, Máté Dobó, Péter Horváth, Eszter Kiss, Lívia Budai, Judit Dobos, Tamás Pálla, László Őrfi, Gergely Völgyi, Gergő Tóth
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:Heliyon
Subjects:
Pomalidomide
Cyclodextrin complexation
Inclusion complex
Solubility
Comparative dissolution
Pomalyst®
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844021016844

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http://www.sciencedirect.com/science/article/pii/S2405844021016844

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