New therapeutic approach: diphenyl diselenide reduces mitochondrial dysfunction in acetaminophen-induced acute liver failure.

New therapeutic approach: diphenyl diselenide reduces mitochondrial dysfunction in acetaminophen-induced acute liver failure.

The acute liver failure (ALF) induced by acetaminophen (APAP) is closely related to oxidative damage and depletion of hepatic glutathione, consequently changes in cell energy metabolism and mitochondrial dysfunction have been observed after APAP overdose. Diphenyl diselenide [(PhSe)2], a simple orga...

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Bibliographic Details
Main Authors: Nélson R Carvalho, Edovando F da Rosa, Michele H da Silva, Cintia C Tassi, Cristiane L Dalla Corte, Sara Carbajo-Pescador, Jose L Mauriz, Javier González-Gallego, Félix A Soares
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3859582?pdf=render

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http://europepmc.org/articles/PMC3859582?pdf=render

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