Morphing of Ibogaine: A Successful Attempt into the Search for Sigma-2 Receptor Ligands

Morphing of Ibogaine: A Successful Attempt into the Search for Sigma-2 Receptor Ligands

Ibogaine is a psychoactive indole alkaloid with high affinity for several targets including the <i>σ</i><sub>2</sub> receptor. Indeed, extensive data support the involvement of the <i>σ</i><sub>2</sub> receptor in neurological disorders, including Alzh...

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Bibliographic Details
Main Authors: Giuseppe Floresta, Maria Dichiara, Davide Gentile, Orazio Prezzavento, Agostino Marrazzo, Antonio Rescifina, Emanuele Amata
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:International Journal of Molecular Sciences
Subjects:
sigma-2 receptor
TMEM97
scaffold-hopping
molecular docking
Ibogaine
Pinoline
Incazane
Online Access:https://www.mdpi.com/1422-0067/20/3/488

Internet

https://www.mdpi.com/1422-0067/20/3/488

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