Elevating CDCA3 levels in non-small cell lung cancer enhances sensitivity to platinum-based chemotherapy

Elevating CDCA3 levels in non-small cell lung cancer enhances sensitivity to platinum-based chemotherapy

Kildey et al find that high levels of mitotic regulator CDCA3 correlates with sensitivity to platinum agents in non-small cell lung cancer patients and cell lines. They show that interfering with CDCA3 degradation through CK2 inhibition enhances CDCA3 levels and increases sensitivity to platinum age...

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Bibliographic Details
Main Authors: Katrina Kildey, Neha S. Gandhi, Katherine B. Sahin, Esha T. Shah, Eric Boittier, Pascal H. G. Duijf, Christopher Molloy, Joshua T. Burgess, Sam Beard, Emma Bolderson, Amila Suraweera, Derek J. Richard, Kenneth J. O’Byrne, Mark N. Adams
Format: Article
Language:English
Published: Nature Publishing Group 2021-05-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-021-02136-8

Internet

https://doi.org/10.1038/s42003-021-02136-8

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