Elevating CDCA3 levels in non-small cell lung cancer enhances sensitivity to platinum-based chemotherapy
Kildey et al find that high levels of mitotic regulator CDCA3 correlates with sensitivity to platinum agents in non-small cell lung cancer patients and cell lines. They show that interfering with CDCA3 degradation through CK2 inhibition enhances CDCA3 levels and increases sensitivity to platinum age...
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2021-05-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-021-02136-8 |
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doaj-1fca8dd3265e4aecb2ae8d295b050bfa2021-05-30T11:30:42ZengNature Publishing GroupCommunications Biology2399-36422021-05-014111210.1038/s42003-021-02136-8Elevating CDCA3 levels in non-small cell lung cancer enhances sensitivity to platinum-based chemotherapyKatrina Kildey0Neha S. Gandhi1Katherine B. Sahin2Esha T. Shah3Eric Boittier4Pascal H. G. Duijf5Christopher Molloy6Joshua T. Burgess7Sam Beard8Emma Bolderson9Amila Suraweera10Derek J. Richard11Kenneth J. O’Byrne12Mark N. Adams13Institute of Health and Biomedical Innovation, School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Translational Research InstituteInstitute of Health and Biomedical Innovation, School of Mathematical Sciences, Faculty of Science and Engineering, Queensland University of TechnologyInstitute of Health and Biomedical Innovation, School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Translational Research InstituteInstitute of Health and Biomedical Innovation, School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Translational Research InstituteInstitute of Health and Biomedical Innovation, School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Translational Research InstituteInstitute of Health and Biomedical Innovation, School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Translational Research InstituteInstitute of Health and Biomedical Innovation, School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Translational Research InstituteInstitute of Health and Biomedical Innovation, School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Translational Research InstituteInstitute of Health and Biomedical Innovation, School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Translational Research InstituteInstitute of Health and Biomedical Innovation, School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Translational Research InstituteInstitute of Health and Biomedical Innovation, School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Translational Research InstituteInstitute of Health and Biomedical Innovation, School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Translational Research InstituteInstitute of Health and Biomedical Innovation, School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Translational Research InstituteInstitute of Health and Biomedical Innovation, School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Translational Research InstituteKildey et al find that high levels of mitotic regulator CDCA3 correlates with sensitivity to platinum agents in non-small cell lung cancer patients and cell lines. They show that interfering with CDCA3 degradation through CK2 inhibition enhances CDCA3 levels and increases sensitivity to platinum agents suggesting a therapeutic route.https://doi.org/10.1038/s42003-021-02136-8 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Katrina Kildey Neha S. Gandhi Katherine B. Sahin Esha T. Shah Eric Boittier Pascal H. G. Duijf Christopher Molloy Joshua T. Burgess Sam Beard Emma Bolderson Amila Suraweera Derek J. Richard Kenneth J. O’Byrne Mark N. Adams |
| spellingShingle |
Katrina Kildey Neha S. Gandhi Katherine B. Sahin Esha T. Shah Eric Boittier Pascal H. G. Duijf Christopher Molloy Joshua T. Burgess Sam Beard Emma Bolderson Amila Suraweera Derek J. Richard Kenneth J. O’Byrne Mark N. Adams Elevating CDCA3 levels in non-small cell lung cancer enhances sensitivity to platinum-based chemotherapy Communications Biology |
| author_facet |
Katrina Kildey Neha S. Gandhi Katherine B. Sahin Esha T. Shah Eric Boittier Pascal H. G. Duijf Christopher Molloy Joshua T. Burgess Sam Beard Emma Bolderson Amila Suraweera Derek J. Richard Kenneth J. O’Byrne Mark N. Adams |
| author_sort |
Katrina Kildey |
| title |
Elevating CDCA3 levels in non-small cell lung cancer enhances sensitivity to platinum-based chemotherapy |
| title_short |
Elevating CDCA3 levels in non-small cell lung cancer enhances sensitivity to platinum-based chemotherapy |
| title_full |
Elevating CDCA3 levels in non-small cell lung cancer enhances sensitivity to platinum-based chemotherapy |
| title_fullStr |
Elevating CDCA3 levels in non-small cell lung cancer enhances sensitivity to platinum-based chemotherapy |
| title_full_unstemmed |
Elevating CDCA3 levels in non-small cell lung cancer enhances sensitivity to platinum-based chemotherapy |
| title_sort |
elevating cdca3 levels in non-small cell lung cancer enhances sensitivity to platinum-based chemotherapy |
| publisher |
Nature Publishing Group |
| series |
Communications Biology |
| issn |
2399-3642 |
| publishDate |
2021-05-01 |
| description |
Kildey et al find that high levels of mitotic regulator CDCA3 correlates with sensitivity to platinum agents in non-small cell lung cancer patients and cell lines. They show that interfering with CDCA3 degradation through CK2 inhibition enhances CDCA3 levels and increases sensitivity to platinum agents suggesting a therapeutic route. |
| url |
https://doi.org/10.1038/s42003-021-02136-8 |
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