Sex, Pramipexole and Tiagabine Affect Behavioral and Hormonal Response to Traumatic Stress in a Mouse Model of PTSD

Sex, Pramipexole and Tiagabine Affect Behavioral and Hormonal Response to Traumatic Stress in a Mouse Model of PTSD

Posttraumatic stress disorder (PTSD) has been associated with abnormal regulation of the hypothalamic-pituitary-adrenal gland axis (HPA). Women demonstrate a more robust HPA response and are twice as likely to develop PTSD than men. The role of sex hormones in PTSD remains unclear. We investigated w...

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Bibliographic Details
Main Authors: Natalia Malikowska-Racia, Kinga Salat, Joanna Gdula-Argasinska, Piotr Popik
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Pharmacology
Subjects:
Pramipexole
tiagabine
corticosterone
PTSD
trauma
sex
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.691598/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.691598/full

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