HMGB1 and Histones Play a Significant Role in Inducing Systemic Inflammation and Multiple Organ Dysfunctions in Severe Acute Pancreatitis

Severe acute pancreatitis (SAP) starts as a local inflammation of pancreatic tissue that induces the development of multiple extrapancreatic organs dysfunction; however, the underlying mechanisms are still not clear. Ischemia-reperfusion, circulating inflammatory cytokines, and possible bile cytokin...

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Bibliographic Details
Main Authors: Runkuan Yang, Jyrki Tenhunen, Tor Inge Tonnessen
Format: Article
Language:English
Published: Hindawi Limited 2017-01-01
Series:International Journal of Inflammation
Online Access:http://dx.doi.org/10.1155/2017/1817564