Complimentary Methods for Multivariate Genome-Wide Association Study Identify New Susceptibility Genes for Blood Cell Traits

Complimentary Methods for Multivariate Genome-Wide Association Study Identify New Susceptibility Genes for Blood Cell Traits

Genome-wide association studies (GWAS) have found hundreds of novel loci associated with full blood count (FBC) phenotypes. However, most of these studies were performed in a single phenotype framework without putting into consideration the clinical relatedness among traits. In this work, in additio...

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Bibliographic Details
Main Authors: Segun Fatumo, Tommy Carstensen, Oyekanmi Nashiru, Deepti Gurdasani, Manjinder Sandhu, Pontiano Kaleebu
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Genetics
Subjects:
multivariate GWAS
PCA
full blood counts
multiple phenotype
genome-wide association study
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2019.00334/full

Internet

https://www.frontiersin.org/article/10.3389/fgene.2019.00334/full

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