Alternative polyadenylation of mRNA and its role in cancer

Alternative polyadenylation (APA) is a molecular process that generates diversity at the 3′ end of RNA polymerase II transcripts from over 60% of human genes. APA is derived from the existence of multiple polyadenylation signals (PAS) within the same transcript, and results in the differential inclu...

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Bibliographic Details
Main Authors: Fuwen Yuan, William Hankey, Eric J. Wagner, Wei Li, Qianben Wang
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Genes and Diseases
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2352304219300984