Silencing of the Charcot–Marie–Tooth disease-associated gene GDAP1 induces abnormal mitochondrial distribution and affects Ca2+ homeostasis by reducing store-operated Ca2+ entry

Silencing of the Charcot–Marie–Tooth disease-associated gene GDAP1 induces abnormal mitochondrial distribution and affects Ca2+ homeostasis by reducing store-operated Ca2+ entry

GDAP1 is an outer mitochondrial membrane protein that acts as a regulator of mitochondrial dynamics. Mutations of the GDAP1 gene cause Charcot–Marie–Tooth (CMT) neuropathy. We show that GDAP1 interacts with the vesicle-organelle trafficking proteins RAB6B and caytaxin, which suggests that GDAP1 may...

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Bibliographic Details
Main Authors: David Pla-Martín, Carlos B. Rueda, Anna Estela, Maribel Sánchez-Piris, Paloma González-Sánchez, Javier Traba, Sergio de la Fuente, Luca Scorrano, Jaime Renau-Piqueras, Javier Alvarez, Jorgina Satrústegui, Francesc Palau
Format: Article
Language:English
Published: Elsevier 2013-07-01
Series:Neurobiology of Disease
Subjects:
GDAP1
Charcot–Marie–Tooth disease
Mitochondrial distribution and motility
Endoplasmic reticulum
Calcium homeostasis
Store-operated Ca2+ entry
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996113000983

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http://www.sciencedirect.com/science/article/pii/S0969996113000983

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