P-glycoprotein Mediated Efflux Limits Substrate and Drug Uptake in a Preclinical Brain Metastases of Breast Cancer Model

P-glycoprotein Mediated Efflux Limits Substrate and Drug Uptake in a Preclinical Brain Metastases of Breast Cancer Model

The blood-brain barrier (BBB) is a specialized vascular interface that restricts the entry of many compounds into brain. This is accomplished through the sealing of vascular endothelial cells together with tight junction proteins to prevent paracellular diffusion. In addition, the BBB has a high deg...

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Bibliographic Details
Main Authors: Chris E Adkins, Rajendar Kumar Mittapalli, Vamshi Krishna Manda, Mohamed Ismail Nounou, Afroz Shareef Mohammad, Tori Breanne Terrrell, Kaci Ann Bohn, Celik eYasemin, Tiffany Renee Grothe, Julie Ann Lockman, Paul Richard Lockman
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-11-01
Series:Frontiers in Pharmacology
Subjects:
Autoradiography
Drug Resistance
chemotherapy
tumor
fluorescence microscopy
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2013.00136/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2013.00136/full

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