Comprehensive evaluation of genome-wide 5-hydroxymethylcytosine profiling approaches in human DNA

Comprehensive evaluation of genome-wide 5-hydroxymethylcytosine profiling approaches in human DNA

Abstract Background The discovery that 5-methylcytosine (5mC) can be oxidized to 5-hydroxymethylcytosine (5hmC) by the ten-eleven translocation (TET) proteins has prompted wide interest in the potential role of 5hmC in reshaping the mammalian DNA methylation landscape. The gold-standard bisulphite c...

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Bibliographic Details
Main Authors: Ksenia Skvortsova, Elena Zotenko, Phuc-Loi Luu, Cathryn M. Gould, Shalima S. Nair, Susan J. Clark, Clare Stirzaker
Format: Article
Language:English
Published: BMC 2017-04-01
Series:Epigenetics & Chromatin
Subjects:
DNA methylation
Methylome
Epigenetics
5-Hydroxymethylation
HM450K Bis/OxBis
hMeDIP-seq
Online Access:http://link.springer.com/article/10.1186/s13072-017-0123-7

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http://link.springer.com/article/10.1186/s13072-017-0123-7

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