A New Symmetrical Thiazolidinedione Derivative: In Silico Design, Synthesis, and In Vivo Evaluation on a Streptozotocin-Induced Rat Model of Diabetes

A New Symmetrical Thiazolidinedione Derivative: In Silico Design, Synthesis, and In Vivo Evaluation on a Streptozotocin-Induced Rat Model of Diabetes

By activating PPAR-γ, thiazolidinediones normalize glucose levels in animal models of type 2 diabetes and in patients with this pathology. The aim of the present study was to analyze 219 new derivatives in silico and select the best for synthesis, to be evaluated for acute oral toxicity in female ra...

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Bibliographic Details
Main Authors: Samuel Álvarez-Almazán, Gabriel Navarrete-Vázquez, Itzia Irene Padilla-Martínez, José Correa-Basurto, Diana Alemán-González-Duhart, Feliciano Tamay-Cach, Jessica Elena Mendieta-Wejebe
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Processes
Subjects:
in silico study
thiazolidinedione
pioglitazone
streptozotocin
diabetes model
Knoevenagel condensation
Online Access:https://www.mdpi.com/2227-9717/9/8/1294

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https://www.mdpi.com/2227-9717/9/8/1294

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