A Lassa Fever Live-Attenuated Vaccine Based on Codon Deoptimization of the Viral Glycoprotein Gene

A Lassa Fever Live-Attenuated Vaccine Based on Codon Deoptimization of the Viral Glycoprotein Gene

Lassa virus (LASV) infects several hundred thousand people in Western Africa, resulting in many lethal Lassa fever (LF) cases. Licensed LF vaccines are not available, and anti-LF therapy is limited to off-label use of the nucleoside analog ribavirin with uncertain efficacy. We describe the generatio...

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Bibliographic Details
Main Authors: Yingyun Cai, Chengjin Ye, Benson Cheng, Aitor Nogales, Masaharu Iwasaki, Shuiqing Yu, Kurt Cooper, David X. Liu, Randy Hart, Ricky Adams, Tyler Brady, Elena N. Postnikova, Jonathan Kurtz, Marisa St Claire, Jens H. Kuhn, Juan Carlos de la Torre, Luis Martínez-Sobrido
Format: Article
Language:English
Published: American Society for Microbiology 2020-02-01
Series:mBio
Subjects:
arenaviridae
arenavirid
arenavirus
bunyavirales
bunyavirus
guinea pig
lassa
lassa fever
lassa virus
lasv
lav
live-attenuated vaccine
mammarenavirus
strain 13
vaccine
vhf
viral hemorrhagic fever
Online Access:https://doi.org/10.1128/mBio.00039-20

Internet

https://doi.org/10.1128/mBio.00039-20

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