nc886 is induced by TGF-β and suppresses the microRNA pathway in ovarian cancer

nc886 is induced by TGF-β and suppresses the microRNA pathway in ovarian cancer

Ovarian cancers often display elevated TGF-β signaling but repressed miRNA expression. Here the authors identify that non-coding RNA nc886 expression is induced by TGF-β, which then binds to DICER and impairs miRNA maturation.

Bibliographic Details
Main Authors: Ji-Hye Ahn, Hyun-Sung Lee, Ju-Seog Lee, Yeon-Su Lee, Jong-Lyul Park, Seon-Young Kim, Jung-Ah Hwang, Nawapol Kunkeaw, Sung Yun Jung, Tae Jin Kim, Kwang-Soo Lee, Sung Ho Jeon, Inhan Lee, Betty H. Johnson, Jung-Hye Choi, Yong Sun Lee
Format: Article
Language:English
Published: Nature Publishing Group 2018-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-03556-7

Internet

https://doi.org/10.1038/s41467-018-03556-7

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