Methylation of the Suppressor Gene <i>p16INK4a</i>: Mechanism and Consequences
Tumor suppressor genes in the <i>CDKN2A/B</i> locus (<i>p15INK4b</i>, <i>p16INK4a</i>, and <i>p14ARF</i>) function as biological barriers to transformation and are the most frequently silenced or deleted genes in human cancers. This gene silencing freq...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-03-01
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| Series: | Biomolecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-273X/10/3/446 |