Inhibition of CCL2 Signaling in Combination with Docetaxel Treatment Has Profound Inhibitory Effects on Prostate Cancer Growth in Bone

Inhibition of CCL2 Signaling in Combination with Docetaxel Treatment Has Profound Inhibitory Effects on Prostate Cancer Growth in Bone

The C-C chemokine ligand 2 (CCL2) stimulates migration, proliferation, and invasion of prostate cancer (PCa) cells, and its signaling also plays a role in the activation of osteoclasts. Therefore targeting CCL2 signaling in regulation of tumor progression in bone metastases is an area of intense res...

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Bibliographic Details
Main Authors: Eva Corey, Robert L. Vessella, Linda A. Snyder, Holly M. Nguyen, Lisha G. Brown, Theodore Koreckij, Peter S. Kirk
Format: Article
Language:English
Published: MDPI AG 2013-05-01
Series:International Journal of Molecular Sciences
Subjects:
prostate cancer
bone metastases
chemokine
CCL2
docetaxel
Online Access:http://www.mdpi.com/1422-0067/14/5/10483

Internet

http://www.mdpi.com/1422-0067/14/5/10483

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