The Effect of Shiga Toxin on Weibel-Palade Bodies in Primary Human Endothelial Cells

Background/Aims: Diarrhea-associated hemolytic uremic syndrome is associated with the presence of Shiga toxin (Stx1, Stx2 and several variants) in the circulation. The aim of this study is to examine the possible triggering effect of Stx1 on the exocytosis of Weibel-Palade bodies (WPbs). Methods: Cu...

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Bibliographic Details
Main Authors: Joyce Geelen, Maartje van den Biggelaar, Peter Linssen, Thea van der Velden, Koen Mertens, Leo Monnens
Format: Article
Language:English
Published: Karger Publishers 2014-07-01
Series:Nephron Extra
Subjects:
Online Access:http://www.karger.com/Article/FullText/363299