Identification of the toxic threshold of 3-hydroxybutyrate-sodium supplementation in septic mice

Identification of the toxic threshold of 3-hydroxybutyrate-sodium supplementation in septic mice

Abstract Background In septic mice, supplementing parenteral nutrition with 150 mg/day 3-hydroxybutyrate-sodium-salt (3HB-Na) has previously shown to prevent muscle weakness without obvious toxicity. The main objective of this study was to identify the toxic threshold of 3HB-Na supplementation in se...

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Bibliographic Details
Main Authors: Ruben Weckx, Chloë Goossens, Sarah Derde, Lies Pauwels, Sarah Vander Perre, Greet Van den Bergh, Lies Langouche
Format: Article
Language:English
Published: BMC 2021-09-01
Series:BMC Pharmacology and Toxicology
Subjects:
Critical illness
ICU-acquired weakness
Ketones
Toxicity
Sodium
Metabolic alkalosis
Online Access:https://doi.org/10.1186/s40360-021-00517-7

Internet

https://doi.org/10.1186/s40360-021-00517-7

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