Intrinsically Connected: Therapeutically Targeting the Cathepsin Proteases and the Bcl-2 Family of Protein Substrates as Co-Regulators of Apoptosis

Intrinsically Connected: Therapeutically Targeting the Cathepsin Proteases and the Bcl-2 Family of Protein Substrates as Co-Regulators of Apoptosis

Taken with the growing importance of cathepsin-mediated substrate proteolysis in tumor biology and progression, the focus and emphasis placed on therapeutic design and development is coming into fruition. Underpinning this approach is the invariable progression from the direction of fully characteri...

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Bibliographic Details
Main Authors: Surinder M. Soond, Maria V. Kozhevnikova, Lyudmila V. Savvateeva, Paul A. Townsend, Andrey A. Zamyatnin
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:International Journal of Molecular Sciences
Subjects:
apoptosis
Bcl-2
BH3
extrinsic
intrinsic
MOMP
Online Access:https://www.mdpi.com/1422-0067/22/9/4669

Internet

https://www.mdpi.com/1422-0067/22/9/4669

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